Objective Exploring the predictive value of 18F-FDG PET/CT metabolic parameters and metabolic heteroge-neity index for the efficacy of neoadjuvant chemotherapy in patients with gastric adenocarcinoma.Methods Retrospective analysis of 107 gastric cancer patients receiving neoadjuvant chemotherapy.Collect clinical information of patients,pre treatment 18F-FDG PET/CT images,and postoperative pathological results.Measure the SUVmax1,SUVmean1,MTV,TLG of the primary lesion,SUVmax2 and SUVmean2 of the liver.Calculate heterogeneity index-1(HI-1),heterogeneity index-2(HI-2),and tumor liver uptake ratio(TLR).Analyze the correlation between these semi quantitative parameters and clinical data characteristics of patients with postoperative chemotherapy response(TRG).Results There were statis-tically significant differences(P＜0.05)in T stage,M stage,vascular invasion,nerve invasion,SUVmax1,SUVmean1,MTV,TLG,HI-1,HI-2,and TLR among the same TRG grading group.In multivariate analysis,SUVmax1 and SU-Vmean1 levels,the presence of distant metastasis,and vascular invasion were independent risk factors for predicting the ef-ficacy of neoadjuvant chemotherapy.Conclusion The combination of 18F-FDG PET/CT metabolic parameters and clinical characteristics can predict the efficacy of neoadjuvant chemotherapy in patients with gastric adenocarcinoma to a certain ex-tent.
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