Objective To analyze the risk factors for enteral feeding intolerance(FI)during ventilation therapy in patients with respiratory failure(RF).Methods 124 RF patients who underwent mechanical ventilation treatment in the hospital from Oc-tober 2021 to September 2023 were selected to evaluate the occurrence of enteral nutrition FI during the ventilation treatment period.A general information survey questionnaire was developed to investigate patient related information.Logistic regression analysis was used to test the risk factors for enteral nutrition FI in RF patients during the ventilation treatment period.Results During the venti-lation treatment period,63 out of 124 RF patients experienced enteral nutrition FI,with an incidence rate of 50.81%;Logistic re-gression analysis showed that age≥60 years old,nasal feeding speed>40ml,high acute physiological and chronic health score(APACHE Ⅱ),and synchronous intermittent ventilation were risk factors for enteral nutrition FI during ventilation treatment in RF patients(OR>1,P<0.05);High serum albumin levels are a protective factor for enteral nutrition(FI)during ventilation therapy in RF patients(OR<1,P<0.05).Conclusion Patients with RF have a high risk of developing enteral nutrition(FI)during ventilation therapy,which is influenced by age,nasal feeding speed,APACHE Ⅱ score,synchronous intermittent ventilation mode,and serum albumin level.Based on this,the enteral nutrition plan can be adjusted reasonably,and feeding intervention can be strengthened to reduce the occurrence of FI during ventilation therapy in patients.