Value of CD64 index combined with IL-1β and TLR4 in the diagnosis of postoperative infection of colorectal cancer
Objective To explore the value of CD64 index combined with serum interleukin-1β(IL-1β)and Toll-like receptor 4(TLR4)levels in the diagnosis of postoperative incision infection in patients undergoing colorectal cancer surgery.Methods A total of 113 patients undergoing radical resection of colorectal cancer in our hospital from June 2020 to June 2022 were enrolled as the study subjects.They were divided into infected group and non-infected group according to whether incision infection occurred after surgery.Peripheral blood CD64 index and the levels of serum IL-1β and TLR4 were detected before surgery and 3 and 5 days after surgery.The receiver operating characteristic(ROC)curve was drawn to analyze the value of each indicator and their combination in the diagnosis of postoperative incision infection of colorectal cancer and the relationship between three indicators and severity of incision infection.Results On the 3rd and 5th days after surgery,the CD64 index and levels of serum IL-1β and TLR4 in the infected group were higher than those in the non-infected group,and the three indicators in the infected group on the 3rd day after surgery were significantly in-creased compared with those before surgery.The three indicators in the infected group on the 5th day after surgery were decreased com-pared with those on the 3rd day after surgery,but they were still higher than those before surgery,with statistical differences(P＜0.05).There were no significant differences in CD64 index and serum IL-1β and TLR4 levels in the non-infected group before surgery and on the 3rd and 5th days after surgery(P＞0.05).The ROC curve drawn with each indicator on the 3rd day after surgery showed that the areas under the ROC curve(AUCROC)of CD64 index,serum IL-1β and TLR4,and their combination in predicting the postoperative infec-tion of colorectal cancer were 0.937,0.901,0.790,and 0.997(95%CI:0.992-1.000),respectively,indicating that each indicator a-lone could better predict the postoperative infection of colorectal cancer,and the combination of the three indicators might have the best predictive efficiency.Conclusion Peripheral blood CD64 index and serum IL-1β and TLR4 levels have good efficiency in predicting the postoperative incision infection of colorectal cancer,and their combined application has the highest predictive efficiency,which can be used as early predictors for the clinical screening of postoperative infection.
radical resection of colorectal cancerpostoperative incision infectionCD64 indexseruminterleukin-1βToll-like receptor 4
NETL
NSTL
万方数据
维普
