Association between gene polymorphism of interleukin-6-634C/G and-597G/A and coronary heart disease in Suqian area
Objective To study the correlation between the polymorphisms of the promoter regions of interleukin-6(IL-6)gene-634C/G and-597G/A and coronary heart disease(CHD)in Suqian area.Methods A total of 248 patients with coronary heart dis-ease in Suqian First Hospital from 2022 January to September were enrolled into CHD group and 126 healthy individuals were selected as control group.PCR-RFLP method was used to analyze IL-6 gene polymorphism loci and genotypes in each group,and Hardy Wein-berg balance test was performed.The logistic regression method was used to analyze the relationship between gene polymorphism and coronary heart disease.Further detections were conducted for the levels of biochemical indicators,i.e.,triglycerides(TG),high-densi-ty lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),apolipoprotein A1(apoA1),apolipoprotein B(apoB),total cholesterol(TC),glucose(Glu),as well as C-reactive protein(CRP),glycated hemoglobin(HbA1c)and IL-6 in each group.Results The test results showed that compared with the healthy control group,the CHD group had significantly increased levels of TG,TC,LDL-C,apoB,Glu,CRP,HbA1c and IL-6(P＜0.05),but decreased levels of HDL-C and apoA1(P＜0.05).The logistic regression results showed the CG and GG genotypes in IL-6-634C/G gene were associated with the risk of coronary heart dis-ease,adjusting OR(95%CI)were 2.068(1.410-3.032)and 6.674(2.034-21.900),except for CC genotype,The genotype frequen-cies of CC,CG and GG in the CHD group were 47.9%,39.9%,12.2%,and were 76.2%,21.5%and 2.3%in healthy control group.The frequencies of C and G alleles were 74.7%,25.3%and 82.9%,and 17.1%in the two groups.The patients carrying G alleles had a higher risk of developing CHD than those carrying C alleles,and there were statistically significant differences in genotype and allele frequency between the two groups(both P＜0.05).The IL-6-597G/A gene polymorphism was not associated with susceptibility to CHD.Conclusion The risk of CHD patients in the Suqian region associated with IL-6-634C/G gene polymorphism,but not remarkably asso-ciated with IL-6-597G/A polymorphism.
NETL
NSTL
万方数据
