Predictive values of serum PCT,IL-6,HBP and CRP levels in cerebral infarction complicated with pulmonary infection
Objective To investigate the predictive value of procalcitonin(PCT),interleukin-6(IL-6),heparin binding protein(HBP),and C-reactive protein(CRP)in cerebral infarction(CI)complicated with pulmonary infection.Methods 145 CI patients treated in Jiangning Hospital Affiliated to Nanjing Medical University from July 2022 to June 2023 were selected as the CI group.Ac-cording to whether combined with pulmonary infection,they were divided into the co-infected group(n=76)with pulmonary infection and the simple CI group(n=69)without pulmonary infection.61 healthy volunteers performed physical examination in our hospital at the same time were enrolled as the control group.The general clinical data from each group were collected and their serum biochemical indicators were compared.The multivariate Logistic regression was used to analyze the risk factors of CI complicated with pulmonary in-fection and the receiver operating characteristic(ROC)curve was constructed.The area under the ROC curve(AUCROC)was used to evaluate the diagnostic value of each index for CI complicated with pulmonary infection.Results Age,PCT,IL-6,HBP,and CRP were the independent risk factors of CI complicated with pulmonary infection(P＜0.05).The ROC curve analysis showed that each in-dex of PCT,IL-6,HBP,and CRP had a certain value in predicting CI combined with pulmonary infection.The sensitivity and specific-ity of the combination detection of PCT,IL-6,HBP,and CRP were 85.47%and 75.36%,respectively,which were significantly high-er than that of the single detection of PCT,IL-6,HBP,and CRP(P＜0.05).Conclusion The levels of serum PCT,IL-6,HBP,and CRP are highly expressed in CI patients combined with pulmonary infection.They can be used for the diagnosis of CI combined with pulmonary infection.The combination detection of the four indexes can effectively improve the diagnosis accuracy of CI complicated with pulmonary infection.
pulmonary infectioncerebral infarctionprocalcitonininterleukin-6heparin-binding proteinC-reactive protein
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