Analysis of relationship between drug resistance genotype of HIV and clinical treatment effect for AIDS patients in Nanjing
Objective To analyze the influence of HIV drug resistance genotypes on the outcomes of antiretroviral treatment in AIDS patients.Methods A total of 499 AIDS patients were included as the research subjects.Drug resistance genotypes were detected and compared with the database.Simultaneously,viral load and the absolute counts of CD4+lymphocyte were measured.The genotypes of drug resistance and effects of clinical treatment were analyzed.Results Among the 499 cases studied,409 samples were successfully amplified and sequenced,and 181 cases occurred drug resistance.The patients with drug resistance were significantly older than those without drug resistance,and their CD4+absolute cell counts were significantly lower.Nucleoside reverse transcriptase inhibitors(NR-TI)and non-nucleoside reverse transcriptase inhibitors(NNRTIs)were more likely to develop high-level drug resistance compared to protease inhibitors(PI).Additionally,drug-resistant patients had higher viral loads.Conclusion The overall incidence of drug resist-ance in AIDS patients in Nanjing area is relatively low,but the proportion of multidrug-resistant and highly resistant patients among those with drug resistance is relatively high.During diagnosis and treatment,clinical indicators should be monitored,and antiretroviral treatment plans should be adjusted in a timely manner with preference given to the antiretroviral drugs with high resistance barriers.
NETL
NSTL
万方数据
