首页|南宁地区0～15岁儿童甲状腺功能检测指标参考区间的建立

南宁地区0～15岁儿童甲状腺功能检测指标参考区间的建立

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目的 建立南宁地区0～15岁儿童甲状腺功能检测指标即促甲状腺激素(TSH)、游离甲状腺素(FT4)和游离三碘甲状腺原氨酸(FT3)的参考区间.方法 选取2018年10月至2023年8月在广西中医药大学附属国际壮医医院就诊的0～15岁健康儿童1 289例,采用化学发光微粒子免疫检测法测定血清TSH、FT4和FT3浓度.依据美国临床和实验室标准协会(CLSI)EP28-A3c文件要求,采用非参数百分位法建立南宁地区0～15岁儿童TSH、FT4和FT3的参考区间.结果 TSH(男性)参考区间为:0～＜1 月 0.88～7.81 μIU/mL,1 月～15 岁 0.59～5.06 μIU/mL.TSH(女性)参考区间为:0～＜1 月 0.93～8.42 μIU/mL,1月～15 岁 0.60～4.30 μIU/mL.FT4(男性)参考区间为:0～＜1 月 0.99～1.92 pg/mL,1 月～15 岁 0.86～1.33 pg/mL.FT4(女性)参考区间为:0～＜1 月 1.05～2.06 pg/mL,1 月～15 岁 0.85～1.37 pg/mL.FT3 参考区间为:0～＜1 月 2.16～4.24 pmol/L,1 月～＜11岁2.75～4.49 pmol/L,11～15岁2.45～4.34 pmol/L.不同性别和年龄组间TSH、FT4和FT3水平存在显著性差异(P＜0.05).结论 成功建立了南宁地区0～15岁儿童TSH、FT4和FT3的参考区间,不同性别和年龄组间差异显著.
Establishment of reference interval for detection indicators of thyroid function in children aged 0-15 years in Nanning area of China
Objective To establish the reference intervals for test indicators of thyroid function,namely thyroid stimulating hormone(TSH),free thyroxine(FT4),and free triiodothyronine(FT3),in the children aged 0 to 15 years old in Nanning,China.Methods A total of 1 289 healthy children aged 0 to 15 years old who attended the Guangxi International Zhuang Medicine Hospital Affiliated with Guangxi University of Chinese Medicine from October 2018 to August 2023 were selected.The concentrations in serum TSH,FT4,and FT3 were measured by chemiluminescent microparticle immunoassay(CMIA).According to the Clinical and Laboratory Standards Institute(CLSI)EP28-A3c guideline,the nonparametric percentile method was used to establish the reference intervals for TSH,FT4,and FT3 in the children aged 0 to 15 years old in Nanning area.Results The established reference intervals were as follows:TSH(male):0 to＜1 month:0.88-7.81 µIU/mL,1 month to 15 years:0.59-5.06 μIU/mL;TSH(female):0 to＜1 month:0.93-8.42μIU/mL,1 month to 15 years:0.60-4.30 μIU/mL.FT4(male):0 to＜1 month:0.99-1.92 pg/mL,1 month to 15 years:0.86-1.33 pg/mL;FT4(female):0 to＜1 month:1.05-2.06 pg/mL,1 month to 15 years:0.85-1.37 pg/mL;FT3:0 to＜1 month:2.16-4.24 pmol/L,1 month to＜11 years:2.75-4.49 pmol/L,11 to 15 years:2.45-4.34 pmol/L.Significant differences were observed among different gender and age groups for TSH,FT4,and FT3 levels(P＜0.05).Conclusion This study successfully established the refer-ence intervals of TSH,FT4,and FT3 in the children aged 0 to 15 years old in Nanning area,which were significantly different among various gender and age groups.

thyroid stimulating hormonefree thyroxinefree triiodothyroninechemiluminescent microparticle immunoassaychil-drenreference interval

黎思婷、张席玥、周冬谊、易莉玲、樊孟丽、陆柳艺、朱春玲、彭契六

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广西中医药大学附属国际壮医医院检验科,南宁 530201

广西中医药大学附属国际壮医医院康复医学科,南宁 530201

促甲状腺激素 游离甲状腺素 游离三碘甲状腺原氨酸 化学发光微粒子免疫法 儿童 参考区间

国家卫生健康委医院管理研究所重点课题广西国际壮医医院优势学科项目(临床检验诊断学)广西国际壮医医院"青苗工程"培育项目

JYHRJG2024B16院字[2021]33号2022001

2024

10.13602/j.cnki.jcls.2024.08.11

临床检验杂志
江苏省医学会

临床检验杂志

CSTPCD
影响因子：0.746
ISSN：1001-764X
年,卷(期)：2024.42(8)