Regional and mesenchymal cellular expression of COMP in oral squamous cell carcinoma and their signifi-cance
Objective:Expression and clinical significance of cartilage oligomeric matrix protein(COMP)was studied in mesenchymal cells from different regions of oral squamous cell carcinoma(OSCC).Methods:COMP gene expression was first analyzed using the The Cancer Genome Atlas(TCGA)database.Paraffin-embedded sections of 104 OSCC tissues were collected at Nanjing Stomatological Hospital.The sections were stained by immunohistochemistry(IHC)and focused on fibro-blast-like cells(FLCs)and tumor-infiltrating lymphocytes(TILs)at tumor center(TC)and invasive tumor front(ITF)area.Re-sults:TCGA dataset and IHC results showed that the expression level of COMP was significantly higher in OSCC tissues than that in adjacent tissues.Moreover,regional expression analysis suggested that COMP expression in FLCs were higher at ITF than at TC.Chi-square tests revealed that COMP expression in TILs at TC and in FLCs at ITF were associated with relapse,and COMP expression in TILs both at TC and ITF were associated with depth of invasion(DOI).Kaplan-Meier survival anal-ysis indicated that high expression of COMP in FLCs at IFT and in TILs at TC significantly associated with poor survivals of OSCC patients.Cox regression analysis illustrated that high expression of COMP in FLCs at IFT significantly associated with reduced disease-free survival(DFS).Conclusion:High expression of COMP in FLCs at invasive tumor front area could be an independent risk factor affecting prognosis of OSCC patients.
国家科技期刊平台
NSTL
万方数据
