Clinical analysis of oral squamous cell carcinoma and mutant TP53 and PD-1 expression and correlation
Objective:To investigate the effect of TP53 mutation on programmed death receptor-1(PD-1)expression in the tumour microenvironment in oral squamous cell carcinoma.Methods:Oral squamous cell carcinoma patients were taken as research subjects,and specimens of cancer foci,paracancerous and peripheral blood were collected respectively,while their clinical data were collated.The TP53 gene mutation status and PD-1 protein expression of the patients were detected by the whole-exon sequencing method and pathological detection.Results:A total of 12 oral squamous cell carcinoma patients were enrolled,among whom 7(58.3%)had TP53 gene mutation and 7(58.3%)had positive PD-1 protein expression.There was no statistically significant correlation between the expression of PD-1 protein and the age,gender,tumour size and cervical lymph node metastasis of the patients,nor was there any correlation between the TP53 gene mutation and the age,gender,tumour size and cervical lymph node metastasis of the patients.There was also no correlation between TP53 gene variants and patients'age,gender,tumour size and cervical lymph node metastasis.Conclusion:TP53 gene mutations in oral squamous cell carcinoma patients may be correlated with the expression of PD-1 in the tumour microenvironment,and TP53 gene muta-tions have the potential to be used as a marker for immunotherapy heat in oral squamous cell carcinoma.
Oral squamous cell carcinomaProgrammed death receptor-1(PD-1)TP53Immunotherapy
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