Correlation between self-reported periodontal symptoms and subgingival microbiome
Objective:To analyze the impact of self-reported periodontal symptoms on the subgingival microbiome.Methods:Collection of subgingival plaque samples and self-reported periodontal symptom questionnaires in people with dif-ferent periodontal statuses.16S rRNA gene sequencing was used to detect subgingival microorganisms.Linear discriminant analysis was used to compare different microorganisms between groups.Results:A total of 60 participants were enrolled.Self-reported periodontal symptoms were associated with the enrichment of different microorganisms.Streptococcus(P=0.030)was significantly enriched in the group without gingival bleeding.The highest relative abundance of Porphyromonas gingivalis(P.gingivalis,P=0.014)was found in the group with gingival bleeding">1 year".Treponema brennaborense(T.brennabo-rense,P=0.035)had the highest relative abundance in the gingival swelling and pain">1 year"group.Campylobacter concisus(C.concisus,P=0.020)had the highest relative abundance in the oral malodor">1 year"group.Conclusion:Periodontal symptoms in the">1 year"group were associated with periodontal pathogens,which could be useful for risk warning and moni-toring of periodontal disease.The Streptococcus spp.were associated with the absence of periodontal symptoms and may be candidates for probiotic research.
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