Focal therapy for prostate cancer aims to selectively ablate tumor while protecting important ana-tomical structures such as the neurovascular bundle, sphincter, and urethra at the same time, thus minimizing complications and maintaining ideal oncological outcomes. To achieve this, doctors need effective imaging methods to locate the index lesions, as well as precise biopsy methods for pathological diagnosis and focal treatment. This article will discuss the feasibility of focal therapy for prostate cancer, provide an overview of its status quo, and envision its prospect.