目的:越来越多的证据表明反式脂肪酸(trans-fatty acids,TFAs)会影响人们的健康状况.然而,循环TFA浓度与总前列腺特异性抗原(prostate-specific antigen,PSA)之间是否存在关系尚不清楚.因此,本文在美国国家健康与营养调查(National Health and Nutrition Examination Survey,NHANES)数据库的基础上进行了一项横断面人群研究,以分析血浆TFAs和总PSA浓度之间的关系.方法:经过筛选,从NHANES数据库2009-2010年周期中纳入312名参与者.采用单变量、多变量线性回归模型和分层分析检验血浆TFAs(棕榈反油酸、反式异油酸、反油酸、反式亚油酸)浓度与血清总PSA浓度的相关性.结果:在充分调整混杂变量后,数据显示,在老年男性患者中每增加1个单位的log2转换的反式亚油酸,总PSA浓度增加1.14 ng/mL(P＜0.05).然而棕榈反油酸、反式异油酸、反油酸与总PSA浓度无相关性.此外,分层分析显示反式亚油酸与总PSA浓度的相关性在无体力活动参与者间存在显著差异,表明这种正相关性与参与者无体力活动显著相关(交互作用检验P＜0.05).结论:总PSA浓度的升高与上升的循环反式亚油酸浓度相关.这种关系在无体力活动的患者中被进一步放大.因此,反式脂肪酸的摄入可能会导致正常人患前列腺癌的风险增高,尤其是在无体力活动的人群里.减少反式脂肪酸的摄入,有助于身体健康.
Relationship between circulating trans-fatty acids and total PSA concentration in elderly men based on the NHANES database
Objective:There is increasing evidence revealing that trans-fatty acids(TFAs)contribute to poor health.However,whether there is relationship between circulating TFAs and prostate-specific antigen(PSA)re-mains unclear.Herein,we conduct a cross-sectional population study to analyze the association between circulat-ing TFAs and total PSA concentrations on the basis of the US.National Health and Nutrition Examination Survey(NHANES)database.Methods:After conducting the screening,312 participants fit into our study from NHANES(2009-2010).The univariate and multivariable linear regression model and stratified analysis were used to test the association between concentrations of circulating TFAs(palmitelaidic acid,vaccenic acid,elaidic acid and linoelaidic acid)and total PSA concentration.Results:After fully adjustment for confounding variables,the data revealed that the total PSA concentration increased by 1.14 ng/mL for each additional unit of log2-linoe-laidic with P＜0.05.However,there was no association between palmitelaidic acid,vaccenic acid,elaidic acid and total PSA concentration.In further stratified analysis,positive association between linoelaidic acid and total PSA was observed in participants with no physical activity with statistical significance.Conclusion:Increased total PSA concen-tration was associated with elevated linoelaidic acid concentration.The relationship was further amplified in patients with no physical activity.Therefore,TFAs intake may contribute to the increased risk of prostate cancer in normal individuals,especially in participants with no physical activity.Reducing the intake of TFAs,could contribute to a healthy body.
trans-fatty acidstotal prostate specific antigen concentrationNational Health and Nutrition Examination Survey databasecross-sectional study
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