Objective:To investigate the influencing factors of urinary tract infectious fever in patients with u-reteral calculi after ureteroscopic lithotripsy as well as the constituent ratio and drug sensitivity of pathogenic bac-teria before operation.Methods:A total of 253 patients who underwent ureteroscopic lithotripsy in Affiliated Hua-ian No.1 People's Hospital of Nanjing Medical University from June 2019 to September 2022 were retrospectively analyzed.The patients were divided into fever group and control group according to whether or not they developed postoperative urinary tract infectious fever.Univariate and multivariate logistic regression were used to analyze the influencing factors of postoperative urinary tract infectious fever.The constituent ratio and drug sensitivity of pathogenic bacteria in urine culture before operation were analyzed.Results:Of the 253 patients,38 cases devel-oped urinary tract infectious fever after operation,and 57 cases had positive urine culture before operation.There were significant differences in sex,number of stones,preoperative urine culture,preoperative serum creatinine and preoperative serum albumin between the fever group and the control group(P＜0.05).Multivariate logistic regression analysis showed that female,multiple calculi,positive urine culture before operation and low serum al-bumin before operation were independent risk factors of postoperative urinary tract infectious fever(P＜0.05).The highest detection rate of gram-negative bacterium was Escherichia coli(21 strains),which was more sensitive to imipenem,piperacillin/tazobactam and amikacin;The high detection rates of gram-positive bacteria were Strep-tococcus agalactiae(5 strains),Enterococcus faecalis(5 strains)and Staphylococcus epidermidis(4 strains).Strep-tococcus agalactiae was more sensitive to ampicillin.Enterococcus faecalis was more sensitive to ampicillin,peni-cillin,linezolid,streptomycin and vancomycin.Staphylococcus epidermidis was more sensitive to gentamicin,lin-ezolid,vancomycin,tegacycline and rifampicin.Conclusion:For female,patients with multiple calculi,positive u-rine culture before operation and low serum albumin before operation,the prevention of postoperative urinary tract infectious fever should be strengthened.The main pathogens in preoperative urine culture of patients with ureteral calculi were Gram-negative bacteria,especially Escherichia coli.For those with positive urine culture before opera-tion,antibiotics should be used according to the results of drug sensitivity.
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