首页|Galectin-1蛋白在肾透明细胞癌组织中的表达及患者预后判断中的价值

Galectin-1蛋白在肾透明细胞癌组织中的表达及患者预后判断中的价值

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目的:探讨肾透明细胞癌中半乳糖凝集素-1(Galectin-1)蛋白的表达变化,并评估其在患者预后判断方面的潜在价值.方法:采用组织微阵列和免疫组织化学技术对173例肾透明细胞癌组织及其相应的手术切缘正常组织中Galectin-1蛋白表达水平进行检测.收集患者的随访信息,并分析其表达水平与临床病理参数以及患者预后的相关性.结果:免疫组织化学染色结果显示,在173例肾透明细胞癌组织中,28.9％(50/173)的患者Galectin-1蛋白表达水平升高,而在癌旁正常组织中无表达,两者比较差异有统计学意义(P＜0.01).统计分析结果表明,在肾透明细胞癌组织中,Galectin-1蛋白表达水平与T分期、N分期、M分期、坏死区域存在、侵犯肾盂、伴肉瘤样分化以及临床分期均呈显著正相关(均P＜0.05).同时,Galectin-1蛋白的表达水平与肾透明细胞癌患者的预后密切相关.Kaplan-Meier生存曲线显示高表达患者的生存时间明显短于低表达患者(P＜0.05).经过多因素Cox回归分析的进一步验证,Galectin-1的高表达被确认为肾透明细胞癌患者不良预后的独立预测因素.结论:本研究发现肾透明细胞癌组织中Galectin-1蛋白表达水平升高,该高表达与患者预后不良相关,提示Galectin-1有可能成为肾透明细胞癌预后评估的潜在分子标志.
Expression and prognostic value of Galectin-1 protein in clear cell renal cell carcinoma
Objective:To examine alterations in the expression of Galectin-1 protein in clear cell renal cell car-cinoma(ccRCC)and assess its potential significance for predicting patient prognosis.Methods:The Galectin-1 protein expression was assessed using tissue microarrays and immunohistochemistry in surgically-resected tumor tissues and adjacent normal cells obtained from 173 patients with ccRCC.Follow-up data on the patients were gathered,and the analysis involved examining the correlation between Galectin-1 expression levels and clinicopath-ological parameters,as well as assessing its association with patient prognosis.Results:Immunohistochemical staining results showed that Galectin-1 protein was highly expressed in 28.9％(50/173)of ccRCC,while there was no expression in the adjacent normal tissues.There was a significant difference between the two groups(P＜0.01).The statistical analysis results indicate that the protein expression level of Galectin-1 in ccRCC is signifi-cantly positively correlated with T stage,N stage,M stage,presence of necrotic areas,invasion of the renal pel-vis,sarcomatoid differentiation,and clinical stage(P＜0.05).Simultaneously,the protein expression level of Ga-lectin-1 is closely associated with the prognosis of patients with ccRCC.Kaplan-Meier survival curves indicate that the survival time of patients with high expression is significantly shorter than that of patients with low expression(P＜0.05).Further validation through multifactorial Cox regression analysis confirms that the high expression of Galectin-1 is identified as an independent predictor of adverse prognosis in patients with ccRCC.Conclusion:The expression of Galectin-1 protein elevated in ccRCC,suggesting its potential role as a molecular marker for anticipa-ting an unfavorable prognosis in patients with ccRCC.

clear cell renal cell carcinomaimmunohistochemicalGalectin-1prognostic markeroverall survival rate

常晨、毕新刚、常乐

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陕西省人民医院病理科(西安,710068)

国家癌症中心/国家肿瘤临床医学中心/中国医学科学院北京协和医学院肿瘤医院泌尿外科

陕西省人民医院陕西省感染与免疫疾病重点实验室

陕西省人民医院陕西省细胞免疫工程技术研究中心

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肾透明细胞癌 免疫组织化学 半乳糖凝集素-1 预后标志物 总生存率

陕西省自然科学基金陕西省人民医院科技人才支持计划陕西省人民医院科技人才支持计划中国医学科学院医学与健康科技创新工程

2023-JC-QN-08512022JY-442023JY-082021-12M-1-033

2024

10.13201/j.issn.1001-1420.2024.04.009

临床泌尿外科杂志
华中科技大学同济医学院附属协和医院 同济医院

临床泌尿外科杂志

CSTPCD
影响因子：0.734
ISSN：1001-1420
年,卷(期)：2024.39(4)
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