The clinical manifestations,diagnosis,and treatment of postoperative metastasis of rectal cancer to the prostate were explored in order to enhance surgeons'understanding of this disease.A male case of rectal cancer with prostate metastasis was admitted to Sir Run Run Hospital of Nanjing Medical University on May 5th,2020,then we reviewed relevant literature.Combined with the history of rectal adenocarcinoma,prostate and lesion tis-sue sections,and immunohistochemical staining pathology,he was confirmed as rectal adenocarcinoma with pros-tate metastasis.For patients with a history of colorectal cancer,especially those with risk factors such as high clinical stage of colorectal cancer,lymph node metastasis,or vascular invasion,close attention should be paid to and regular inspections should be performed.If the patient has symptoms related to the prostate,such as dysuria,frequent urination,urgency or hematuria,he should be alert to the possibility of prostate metastasis from colorec-tal cancer and conducted with timely assessment and further examination.Also,the pathological or imaging exam-ination should be completed to confirm the diagnosis and avoid misdiagnosis and mistreatment.An individualized treatment plan was chosen according to the patient's condition,including chemotherapy,immunotherapy,targeted therapy,local radiotherapy or surgery.