Clinical study on the association between metabolic syndrome,the incidence and severity of adherent perinephric fat
Objective:To investigate the association between the occurrence,severity of adherent perinephric fat(APF)and the incidence of metabolic syndrome(MS)in patients with renal tumors in clinical practice.Meth-ods:This study included a total of 400 patients who underwent robot-assisted laparoscopic partial nephrectomy at the Department of Urology,Nanjing Drum Tower Hospital,between January 2022 and April 2023.The patients were divided into two groups:a non-adhesion group(197 cases)and an adhesion group with varying degrees of se-verity(mild:84 cases,moderate:100 cases,severe:19 cases).Patient information including age,gender,body mass index(BMI),fasting plasma glucose(FPG),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),smoking and alcohol history,hypertension and diabetes history was recorded.Furthermore,MS was evaluated based on the diagnostic criteria of MS proposed by Chinese Diabetes Society(CDS).Subsequently,a correlation regression analysis was conducted to investigate the association between recorded variables,MS,and the occurrence,severity of APF.Re-sults:The results of the univariate analysis showed that the occurrence of APF was associated with patients'age,gender,BMI,smoking and alcohol history,hypertension,diabetes and MS(P＜0.05).The multivariate analysis revealed that BMI:25-30 kg/m2(OR=2.87[95％CI:1.49-5.52],P=0.002),BMI＞30 kg/m2(OR=4.12[95％CI:1.07-15.91],P=0.040),smoking history(OR=22.12[95％CI:12.72-38.49],P＜0.001),alcohol history(OR=12.63[95％CI:6.64-24.01],P＜0.001),and MS(OR=5.41[95％CI:2.53-12.48],P＜0.001)were independent risk factors in the occurrence of APF.The degree of adhesion was correlated with patients'gender,BMI,smoking,alcohol consumption,hypertension,and MS(P＜0.05).According to the multivariate analysis results,smoking history(OR=4.11[95％CI:2.21-7.64],P＜0.001)and MS(OR=2.01[95％CI:1.12-3.60],P=0.019)were independent risk factors in the severity of APF.Conclusion:The presence and severity of APF in patients diagnosed with renal tumors demonstrate a positive correlation with MS,establishing it as an independent risk factor in the occurrence and severity of APF.Therefore,MS can serve as a predictive factor in preoperative assessment of both the presence and degree of APF in renal tumor patients,providing valuable guidance for selecting appropriate surgical approaches.
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