Predictive diagnostic value of PVI in prostate cancer
Objective:To investigate the diagnostic value of mean platelet volume/platelet count(MPV/PLT,PVI)combined with prostate specific antigen(PSA)for prostate cancer(PCa).Methods:This study included 67 patients with PCa and 79 patients with benign prostatic hyperplasia in Xiaogan Central Hospital from June 2022 to June 2023.General clinical data,PSA,PVI and other indexes of the two groups were collected,and the relation-ship between PVI and clinicopathological features of PCa as well as the diagnostic value of PCa were analyzed by statistical methods.Results:There was no statistically significant difference in age,history of hypertension,histo-ry of diabetes,or history of smoking between PCa and BPH patients;PVI was lower,while NLR,SII,and PSA were higher in PCa patients compared to BPH patients(P＜0.05).There was no statistically significant difference in NLR or SII between PCa in the PSA gray zone and PCa patients;Compared to patients in the PCa group,the decrease of PVI in PCa patients in the PSA gray zone was not significant(P＜0.05).PVI was negatively correla-ted with PSA and SII of PCa patients,with correlation coefficients of-0.315 and-0.435,respectively(P＜0.05).The ROC curve was plotted,and when PVI,NLR,and SII were applied to predictively assess PCa,the area under the curve(AUC)of PVI was the maximum of 0.725(P＜0.01),and the optimal cut-off value was 0.06,at which time the sensitivity was 65.8％and the specificity was 71.6％.The results of applying PVI to draw the ROC curve for predictive assessment of PCa in the gray zone of PSA are shown,with an AUC of 0.726 and an optimal cut-off value of 0.05,at which time the sensitivity and specificity were 64.6％and 68.4％,respec-tively(P＜0.01).Conclusion:PVI has predictive value in the diagnosis of PCa,and PVI also has some predictive value in PCa in the gray zone of PSA.The appropriate use of PVI can improve the positive rate of early screening for PCa.
MPV/PLTprostate specific antigenprostate cancerdiagnostic value
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