Clinical efficacy of salvage radiotherapy after radical prostatectomy and its potential impact on urinary incontinence recovery
Objective:Clinically localized high-risk prostate cancer patients with biochemical recurrence(BCR)or local recurrent disease(LRD)after radical prostatectomy(RP)usually receive salvage radiotherapy(SRT)treat-ment.This article studied the clinical efficacy of patients with localized high risk prostate cancer who developed BCR or LRD after RP and were followed with SRT and its potential impact on urinary incontinence recovery.Methods:The clinical efficacy and its potential impact on urinary incontinence recovery of patients with localized high risk prostate cancer who developed BCR or LRD after RP treatment and were followed with SRT in Second Affiliated Hospital of Hainan Medical University from September 2006 to September 2018 were retrospectively an-alyzed.The primary endpoint was the urinary incontinence rate(UIR).The secondary endpoints were biochemical failure-free survival,distant metastasis-free survival,disease specific survival,and total overall survival.In ad-dition,short-term(90 days)and long-term(after 90 days)adverse events(AEs)to the gastrointestinal(GI)and genitourinary(GU)systems due to radiotherapy were also included in the analysis.Results:A total of 85 patients were included in the study.The median follow-up time was 86(24,152)months.Sixty-five patients(76.5％)had satisfactory urinary control before SRT.After receiving SRT,2(2.4％)and 3(3.5％)of the 65 patients had short-term and long-term CTCAE≥2 urinary incontinence,respectively.Among the remaining 20 patients(23.5％)who had symptoms of urinary incontinence before SRT,1 patient(1.2％)had recovered urine control in the short-and long-term after receiving SRT.The rest of 19(22.4％)patients have remained stable incontinence in the short-term,and 2(2.4％)patients have progressed long-term urinary incontinence.Among all patients,the short-term AEs of GI and GU systems with Grade≥2 were 5(5.9％)and 7(8.2％),and the long-term AEs were 8(9.4％)and 9(10.6％),respectively.The 5-year biochemical failure-free survival,distant metastasis-free survival,total overall survival,and disease specific survival of the patients were 71.8％,85.9％,89.4％,and 95.3％,respectively.Conclusion:Patients with localized high-risk prostate cancer who have BCR or LRD after RP and were followed by SRT have favorable clinical efficacy and acceptable short-term and long-term AEs.SRT treatment has no significant impact on the recovery of urinary incontinence.
NETL
NSTL
万方数据
