Comparison of metabolic markers in prostate cancer patients before and after androgen deprivation therapy
Objective:To investigate the difference of metabolic levels in androgen deprivation therapy(ADT)for the treatment of prostate cancer.Methods:The clinical data of 342 patients with prostate cancer admitted to Urology Center of People's Hospital of Xinjiang Uygur Autonomous Region and Department of Urology of Seventh Affiliated Hospital of Xinjiang Medical University from January 2010 to December 2020 were retrospectively ana-lyzed.ADT was performed in all patients with prostate cancer,and the changes of PSA,blood glucose,blood lip-ids(TC,TG,HDL-C,LDL-C,Lp),LDH,ALP,HGB and BMI were studied before and 5 years after treat-ment.Results:The median PSA level before treatment was 47.72 ng/mL(range:17.93-100.00 ng/mL),and it began to decrease 1 month after the treatment.Blood glucose and ALP levels did not change significantly within 1 month of treatment,but there was an increase starting at 3 months,showing statistically significant difference from the level before treatment(P＜0.05).TC,TG,LDL-C,Lp,LDH,and BMI increased starting at 1 month.HDL-C and HGB began decreasing at 1 month.The differences in the values for all these metabolic mark-ers before and after treatment were statistically significant(P＜0.05).Conclusion:Although ADT effectively re-duced PSA level in patients with prostate cancer,the resulting hypogonadism can cause metabolic abnormalities,such as elevated blood glucose,ALP,LDH,and BMI levels,dyslipidemia,and decreased HGB level.These lev-els should be monitored to ensure appropriate early intervention.
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