Analysis of pathogenic bacterium distribution and antibiotic resistance among urologic patients with urinary infection
Objective:To analyze pathogenic bacterium distribution and antibiotic resistance among urologic patients with urinary infection to provide guidance for the rational selection of antibiotics.Methods:A total of 1966 uropathogens were collected in First Affiliated Hospital of Yangtze University from January 2020 to December 2022.Identification of strains and drug sensitivity test were performed by paper diffusion method respectively.Sta-tistical analysis with Chi-square test was performed by SPSS software.Results:In 1 966 uropathogens,1 332 were gram-negative,491 were gram-positive,and 143 were Candida,accounting for 67.75％,24.97％,7.27％,respec-tively.Among them,Escherichia coli,Enterococcus faecalis,Candida,Klebsiella pneumoniae,Pseudomonas aerugi-nosa were ranked in the top five,accounting for 42.22％,8.60％,7.27％,5.90％,4.78％of the total number of strains,respectively.There was no significant change in the detection rate of pathogenic bacteria between 2020 and 2022.The resistance rates of Escherichia coli to ampicillin,piperacillin,cefotaxime,cefazolin,ciprofloxacin,moxifloxacin,trimethoprim/sulfamethoxazole,tetracycline were＞40％,to meropenem,imipenem were much lower.The resistance rate of Klebsiella pneumoniae to ampicillin/sulbactam was＞40％,and increased significant-ly.Conclusion:Escherichia coli is the main pathogenic bacterial in patients with urinary tract infection.The bacteri-al spectrum and drug sensitivity of the patients have not changed obviously.Clinicians should pay attention to the culture of pathogenic bacteria and drug sensitivity test,and reasonably use antibiotics.
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