Analysis of the distribution of pathogenic bacteria and risk factors of infection caused by indwelling urinary catheter after radical prostatectomy for prostate cancer
Objective:To investigate the distribution of pathogenic bacteria and risk factors in infection caused by in-dwelling urinary catheter after radical prostatectomy for prostate cancer.Methods:The clinical data of 320 radical prosta-tectomy patients who were admitted to Rong County People's Hospital and First Peoples Hospital of Zigong from October 2019 to October 2023 and meet the inclusion and exclusion criteria were collected and analyzed retrospectively.We ana-lyzed the incidence of infection caused by indwelling urinary catheter and the distribution of pathogenic bacteria,the anti-biotic resistance rates of the major gram-negative and gram-positive bacteria.The difference between the clinical data of the infected group and the uninfected group was compared,and the factors affecting the infection caused by indwelling u-rinary catheter after radical prostatectomy were analyzed through the binary logistic regression model.Results:Urinary tract infection occurred in 29 of 320 patients,accounting for 9.06％,and 42 strains of pathogenic bacteria were detected in the 29 patients.Twenty-six strains of gram-negative bacteria accounted for 61.9％,and the most predominant strain was Escherichia coli,while 16 strains of gram-positive bacteria accounted for 38.1％,and the most predominant strain was Staphylococcus aureus.The main resistant drugs for the major gram-negative bacteria(Escherichia coli)were pip-eracillin and ampicillin,while the main resistant drugs for the major gram-positive bacteria(Staphylococcus aureus)were erythromycin,penicillin,and oxacillin.Binary logistic regression model showed that age was not an influential factor in the occurrence of infection due to indwelling urinary catheter after radical prostate cancer surgery(P＞0.05),but history of diabetes mellitus,duration of postoperative catheter tube retention(＞7 d),and preoperative prophylactic antimicrobial drugs were influential factors in the occurrence of infection due to indwelling urinary catheter after radical prostate cancer surgery(P＜0.05).ROC curve analysis showed that the AUCs of history of diabetes mellitus,postoperative catheter tube retention time,and preoperative prophylactic use of antimicrobial drugs to predict the occurrence of infection due to indwelling urinary catheter after radical prostatectomy for prostate cancer were 0.773,0.764,0.781,respectively.The AUC for the occurrence of infection due to indwelling urinary catheter after radical prostate cancer surgery was 0.850,calculated by the prediction model(Prediction model=2.833× History of diabetes mellitus+2.69XPostoperative cathe-ter tube retention time-3.67 × Preoperative prophylactic use of antimicrobial drugs)with a sensitivity and specificity of 77.7％and 93.1％,respectively.Conclusion:The strains of infection due to indwelling urinary catheter after radical pros-tate cancer surgery are mainly gram-negative bacteria.The history of diabetes,postoperative catheter tube retention time(＞7 d),and preoperative prophylactic use of antimicrobials are all influencing factors in the occurrence of infection due to indwelling urinary catheter after radical prostate cancer surgery,which needs much attention.
prostate cancerafter radical surgeryinfection caused by indwelling urinary catheterdistribu-tion of pathogenic bacteriarisk factors
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