Research progress in the key role of corpus cavernosum smooth muscle cell in erectile dysfunction
In recent years,the incidence rate of erectile dysfunction(ED)has been on the rise and has become a common disease of the urinary system.The corpus cavernosum smooth muscle cell(CCSMC),as an important component of the penile erection structure,has a complete relaxation-contraction mechanism that is an important foundation for penile erection.Patients with ED exhibit various pathological changes in CCSMC,such as increased apoptosis,upregulated pyroptosis and ferroptosis,decreased autophagy,increased oxidative stress levels,and phenotypic transformation.This article aims to summarize the research progress in ED focusing on CCSMC,and elucidate the key pathogenic role of CCSMC in ED and its potential therapeutics.
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