The combination of medication and endoscopic anatomic resection for solitary prostate tuberculosis(SPTB)is a method that combines drug therapy with minimally invasive surgery to treat prostate tuberculosis(PTB).This study demonstrates the effectiveness and safety of this treatment strategy through a case report.The patient was a 66-year-old elderly male,presenting with symptoms of prostatitis such as frequent urination,urgen-cy,and pain during urination.After a thorough physical examination and auxiliary tests,including prostate-spe-cific antigen(PSA)testing,urinalysis,imaging studies,and pathological biopsy,the diagnosis of SPTB was con-firmed.The treatment plan was divided into two stages.Firstly,the patient received a three-month course of standardized anti-tuberculosis medication to reduce the pathogen load and control inflammation.Subsequently,to completely eliminate the lesion,endoscopic access to the urethra was used to anatomically resect the prostate gland,preserving the structure and function of the prostate capsule and surrounding tissues.The surgery was suc-cessful,and the patient recovered well postoperatively with smooth urination,no urinary incontinence or signs of tuberculosis spread.This case report demonstrates that drug therapy combined with endoscopic anatomic resection is an effective method for treating SPTB.