Single-center retrospective study on high-frequency irreversible electroporation focal therapy for prostate cancer
Objective:To evaluate the safety,short-term sexual function preservation,and tumor control effects of high-frequency irreversible electroporation(H-FIRE)in the treatment of localized prostate cancer(PCa).Methods:Data were collected from patients who underwent initial treatment with H-FIRE at Shanghai East Hos-pital from September 1st 2022 to April 1st 2024.Information on baseline sexual function questionnaire results,perioperative adverse events,postoperative sexual function questionnaire results,postoperative tPSA levels,post-operative 6-month biopsy results,and recurrence outcomes were recorded and compared before and after the pro-cedure.Results:A total of 77 patients were included.Among them,44 patients(57.1％)were completed the 6-month follow-up,with a statistically significant decrease in average tPSA levels from(9.42±5.34)ng/mL before surgery to(3.33±2.76)ng/mL after surgery(P＜0.000 1).Twenty-four patients(54.5％,24/44)underwent prostate biopsy at 6 months postoperatively,with 5 patients(20.8％,5/24)showing signs of recurrence and sub-sequently choosing a second H-FIRE surgery.Six patients(7.8％,6/77)experienced early postoperative urinary retention due to premature catheter removal,necessitating outpatient catheterization and removal after one week.No other Clavien-Dindo grade Ⅱ complications were observed perioperatively.Fifty-four patients(70.1％,54/77)were completed the preoperative and 1-month postoperative functional questionnaire assessments,with one patient(1.9％,1/54)using pads at 1 month postoperatively compared to none at baseline.There was no statistically significant difference in the International Prostate Symptom Score(IPSS),Quality of Life(QOL)index,or IIEF-5 score at 1 and 6 months postoperatively compared to baseline,except for a slight decrease in the IIEF-5 score at 1 month(P=0.016 9),which gradually returned to baseline by 6 months postoperatively.Conclusion:H-FIRE for prostate cancer demonstrates good short-term tumor control outcomes with a slight negative impact on sexual function in the short term,while effec-tively preserving urinary function and quality of life and reducing the risk of perioperative complications.
high-frequency irreversible electroporationfocal therapyprostate cancerfunctional resultstumor control outcomes
NETL
NSTL
万方数据
