Multimodal fusion ultrasound technology is an emerging imaging technique that combines various imaging methods.It integrates the real-time monitoring,non-invasive nature,and radiation-free advantages of tra-ditional ultrasound with the high-resolution and detailed anatomical structure display of CT and MRI.This paper focuses on the fusion imaging technology of ultrasound with CT and MRI(US-CT and MRI-TRUS)and its appli-cation in urology.In percutaneous nephrolithotomy(PCNL),multimodal fusion ultrasound technology can en-hance stone removal efficiency and reduce the risk of complications through more precise puncture path selection and real-time guidance.In prostate biopsy,the use of MRI and ultrasound fusion imaging can effectively improve the accuracy of prostate cancer lesion localization and reduce the risk of false negatives.With the advancement of medical imaging and artificial intelligence technology,the fusion of ultrasound with CT and MRI is gradually be-coming a reality,providing higher precision imaging support for the diagnosis and treatment in urology.