首页|机器人辅助腹腔镜膀胱癌根治性切除术后回肠膀胱术和输尿管皮肤造口术在老龄患者中的单中心围术期效果及并发症分析

机器人辅助腹腔镜膀胱癌根治性切除术后回肠膀胱术和输尿管皮肤造口术在老龄患者中的单中心围术期效果及并发症分析

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目的:探究在接受机器人辅助腹腔镜膀胱癌根治性切除术(robot-assisted radical cystectomy,RARC)的老龄患者中,回肠膀胱术(ileal conduit,IC)和输尿管皮肤造口术(cutaneous ureterostomy,CU)对其短期内疗效的分析.方法:回顾性分析2016年6月—2024年2月于重庆医科大学附属第一医院泌尿外科行RARC的83例年龄≥65岁患者的临床资料,其中46例行IC,37例行CU.对于纳入患者的基线资料使用倾向性评分匹配(propensity score matching,PSM)调整患者特征后,比较PSM前后2组患者的围手术期和术后30 d预后的结果.结果:PSM前相较于IC组,CU组的年龄较大(P<0.01),年龄校正查尔森合并症指数(age-adjusted Charlson comorbidity index,aCCI)的值较大(P<0.01),手术时间更短(P=0.002),PSM 后 2 组患者在年龄、aC-CI值上差异无统计学意义.在PSM前后,相较于IC组,CU组患者的术后住院时间更短(P=0.002,P=0.022)、术中失血量更少(P<0.001,P=0.005)、术后30 d并发症总发生率更低(P=0.008,P=0.016)、发生漏尿(P=0.013,P=0.028)和肠梗阻(P=0.037,P=0.028)的概率更低.结论:对于合并多种全身疾病、一般情况较差的老龄肌层浸润性膀胱癌的患者,这类人群接受RARC联合CU手术在短期内的疗效可能更佳.
Perioperative outcomes and complications analysis of ileal conduit and cutaneous ureterostomy in elderly patients undergoing robot-assisted radical cystectomy:a single-center study
Objective:To demonstrate the short-term efficacy of ileal conduit(IC)compared with cutaneous ureterostomy(CU)in patients aged 65 years or older undergoing robot-assisted radical cystectomy(RARC).Meth-ods:Clinical data of 83 patients aged 65 years or older who underwent RARC at the Department of Urology,First Affiliated Hospital of Chongqing Medical University from June 2016 to February 2024 were retrospectively ana-lyzed.Among these patients,46 underwent IC and 37 underwent CU.After adjusting patient characteristics using propensity score matching(PSM)based on baseline data of enrolled patients,perioperative outcomes and postoper-ative 30-day prognosis were compared between the two groups of patients before and after PSM.Results:Prior to PSM,the CU group exhibited older age(P<0.01),higher age-adjusted Charlson comorbidity index(aCCI)values(P<0.01),and shorter operation time(P=0.002)compared to the IC group.Post PSM,no statistically signifi-cant differences were observed in age or aCCI values between two groups.Before and after PSM,compared with the IC group,patients in the CU group had a shorter postoperative hospital stay(P=0.002,P=0.022),less in-traoperative blood loss(P<0.001,P=0.005),lower rates of postoperative complications at 30 days(P=0.008,P=0.016),and lower probabilities of developing urinary leakage(P=0.013,P=0.028)and intestinal obstruc-tion(P=0.037,P=0.028).Conclusion:For elderly patients with muscle-invasive bladder cancer who have mul-tiple systemic diseases and poor general conditions,RARC+CU surgery may demonstrate better short-term efficacy.

robot-assisted surgerybladder canceragedileal conduitcutaneous ureterostomy

韩坤、何靖珂、蒋林岑、李云帆、罗雨、苏帅、张金栋、王德林

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重庆医科大学附属第一医院泌尿外科(重庆,400016)

机器人辅助手术 膀胱癌 老龄 回肠膀胱术 输尿管皮肤造口术

重庆市技术创新与应用发展专项重点项目

CSTB2023TIAD-KPX0053

2024

临床泌尿外科杂志
华中科技大学同济医学院附属协和医院 同济医院

临床泌尿外科杂志

CSTPCD
影响因子:0.734
ISSN:1001-1420
年,卷(期):2024.39(9)