Value of urinary TWIST1 gene methylation detection in postoperative monitoring of bladder cancer
Objective:To explore the predictive value of urinary TWIST1 gene methylation detection in post-operative recurrence monitoring of bladder cancer.Methods:Fifty-one patients with non-muscle invasive bladder cancer who underwent transurethral resection of bladder tumor were followed up with TWIST1 gene methylation detection kit.The value of cystoscopy was evaluated,and the clinicopathological data and postoperative recurrence were statistically analyzed.Results:Sixteen patients were detected to have TWIST1 gene methylation in urine.The sensitivity and specificity were 78.9％and 96.8％,respectively.The positive and negative predictive values were 93.7％and 88.5％,respectively,using cystoscopy as the standard.Conclusion:Detection of TWIST1 gene methylation in urine can be used as an effective method to monitor the recurrence of bladder cancer after transure-thral resection of bladder cancer.
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