Comparative analysis of the efficacy between testicular sparing surgery and radical orchiectomy in the treatment of testicular leydig cell tumor
Objective:To explore the appropriate surgical scheme for testicular leydig cell tumor(LCT)and improve the understanding of diagnosis and treatment of the disease.Methods:This study retrospectively analyzed the clinical data of 30 patients with testicular LCT treated in the First Affiliated Hospital of Zhengzhou University from 2013 to 2023.According to the different surgical methods,they were divided into testicular sparing surgery(TSS)group and radical orchiectomy(RO)group.Results:Among the 30 patients,there were 13 cases in TSS group and 17 cases in RO group.There was no significant difference in tumor side,tumor location,operation time,survival time of the last follow-up between the two groups.The age of patients in TSS group was(24.54±11.52)years old,which was significantly less than that in RO group(38.65±15.93)years old.The tumor diam-eter in TSS group was(1.66±0.72)cm,which was significantly less than that in RO group(2.53±1.35)cm.Fourteen patients underwent intraoperative rapid frozen section examination,and the results were consistent with the conventional pathology.All patients'postoperative conventional pathology showed testicular LCT.The TSS group was followed up for(43.38±27.51)months,and the RO group was followed up for(59.41±31.54)months.All patients in the TSS group were benign tumors.One patient in the RO group had postoperative MRI showing multiple lymphadenopathies in the pelvic and inguinal regions,and received 4 cycles of adjuvant chemo-therapy.No tumor recurrence or new metastasis was found in the follow-up at the end of 8 years after operation,and the rest patients had no tumor recurrence.Conclusion:Surgery is the most effective treatment for LCT of tes-tis.Rapid frozen section examination should be performed routinely during the operation.For young patients with smaller tumor diameters,if considering benign conditions,TSS is preferred.
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