Risk factors in progression to severe sepsis in patients with obstructive upper urinary tract infection
Objective:To investigate the risk factors in progression to severe sepsis in patients with obstructive upper urinary tract infection,and to provide evidence for early identification of high-risk patients in clinical prac-tice.Methods:The clinical data of 67 obstructive upper urinary tract infection patients admitted to Affiliated An-qing Municipal Hospital of Anhui Medical University from January 2020 to March 2023 were retrospectively ana-lyzed.According to whether they progressed to severe sepsis or septic shock,the patients were divided into a case group(n=36)and a control group(n=31).The general information,comorbidities,infection-related indicators and other data were compared between the two groups.Univariate and multivariate logistic regression analyses were used to screen independent risk factors.Results:Compared with the control group,the case group had a sig-nificantly higher proportion of diabetes,neutrophil-to-lymphocyte ratio(NLR),serum creatinine,C-reactive pro-tein(CRP)and procalcitonin(PCT)levels,while platelet count and serum albumin levels were significantly lower(P＜0.05).Multivariate logistic regression analysis showed that PCT was an independent risk factor in progres-sion to severe sepsis in obstructive upper urinary tract infection patients(OR=1.101,P＜0.001).Conclusion:PCT is an independent risk factor in assessing the progression to severe sepsis in patients with obstructive upper u-rinary tract infection.For such patients admitted to the emergency department,close monitoring of PCT,NLR,CRP,platelet count,serum albumin and other indicators should be performed to identify high-risk patients early,intervene timely,and improve prognosis.
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