无症状脑梗死患者同型半胱氨酸的临床研究
Correlation between plasma homocysteine and silent brain infarction
钟萍 1吴丹红 2李土明 1吴滢1
作者信息
- 1. 200082 上海中医药大学附属上海市中西医结合医院神经内科
- 2. 上海交通大学医学院附属第三人民医院神经内科
- 折叠
摘要
目的 探讨血浆同型半胱氨酸(Hcy)与无症状脑梗死(SBI)的相关性.方法 收集研究对象213例,其中SBI患者77例,非SBI患者136例,检测患者空腹12小时后静脉血空腹血糖(FBG)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)以及Hcy水平等指标.结果 SBI的患病率为36.2％.年龄、高血压病史、糖尿病史、LDL-C及Hcy升高与无症状脑梗死发生存在相关性,比值比(OR)[95％可信区间(CI)]分别为1.301(1.021 ～3.676;P ＜0.05)、1.599(1.022～3.886;P＜0.01)、1.245 (1.101～2.651;P＜0.01)、1.518(1.017～2.573;P ＜0.05)、1.100(1.032～1.173;P＜0.01).结论 Hcy是SBI的独立危险因素,对≥60岁老年人群检测Hcy,可以识别SBI的高危人群.
Abstract
Objective To investigate the correlation between plasma homocysteine and silent brain infarction.Methods A total of 213 patients were included,and among them 77 with SBI and 136 without SBI.All patients were recorded clinic dates and laboratory parameters after 12 h fasting,which contain FBG,TC,TG,LDL-C,HDL-C,Hcy,et al.Results The frequency of SBI was 36.2％.Reserch was demonstrated that there was a correlation between elevated plasma Hcy levels and SBI (OR 1.780;95 ％ CI 1.002-4.153;P ＜ 0.05).And SBI also associated with age (OR 1.301;95 ％ CI 1.021-3.676;P ＜0.05),HBP(OR 1.599;95％ CI 1.022-3.886;P ＜0.01),DM(OR 1.245;95％ CI 1.101-2.651;P ＜0.01) and LDL-C(OR 1.518;95％CI 1.017-2.573;P＜0.05).Conclusion It suggests that Hcy may be an independent risk factor for the presence of SBI.Plasma Hcy level can be used to identify the high risk group in people at the age of 60 years or above.
关键词
无症状脑梗死/同型半胱氨酸Key words
Silent brain infarction/Homocysteine引用本文复制引用
基金项目
上海市卫计委科研基金资助项目(2012-460)
上海市卫计委科研基金资助项目(201440332)
上海市科委科研基金资助项目(14411972000)
上海市宝山区科委课题(11-E-3)
出版年
2015
NETL
NSTL
维普
万方数据