Objective To analysis the clinical characteristics of pulmonary cryptococcosis(PC)in the non-HIV-infected patients with low peripheral blood lymphocyte count.Methods According to the low limit of normal lymphocyte count in peripheral blood,104 PC patients were divided into low lymphocyte group(32 cases)and control group(72 cases).General clinical data,albumin levels,clinical features,imaging features,treatment methods and prognosis of the two groups were compared.Results In terms of clinical features,age,the proportion with headache,extrapulmonary transmission and central nervous system(CNS)involvement in low lymphocyte group were higher than that in control group,and the proportion of asymptomatic was lower than that in control group;In terms of imaging features,the proportion with nodular mass lesion type in low lymphocyte group was lower than that in control group,and the proportion with accompanying signs of cavity and pleural effusion were higher than those in control group;In terms of treatment and prognosis,the proportion with surgery+antifungal and monoclonal antifungal treatment,complete remission and effective treatment in low lymphocyte group were lower than those in control group,and the proportion of stable and dead were higher than those in control group(P＜0.05).Conclusion PC patients with low lymphocyte count are relatively older and have more clinical symptoms.They are characterized by decreased rate of nodule or mass lesson and increased probability of cavities and pleural effusion as the imaging performance.Moreover,extrapulmonary dissemination is more likely to occur in patients with low lymphocyte count who have a poor prognosis.
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