Objective To explore the value of plasma free 3-methoxy-epinephrine(MN)and free 3-methoxy-norepinephrine(NMN)in clinical diagnosis of pheochromocytoma/paraganglioma(PPGL).Methods A total of 65 PPGL patients were selected as study group,and 65 non-PPGL patients with hypertension were selected as control group.General clinical data and plasma free MN and NMN levels were compared between the 2 groups.According to the different degrees of tumor differentiation,the study group patients were divided into highly differentiated group(39 cases),moderately differentiated group(15 cases)and poorly differentiated group(11 cases).The plasma free MN and NMN levels were compared between the 3 groups.Correlation analysis was performed by Pearson and Spearman correlation analysis.The predictive value of plasma free MN and NMN levels to PPGL was analyzed by receiver operating characteristic(ROC)curve.Results The levels of SBP,DBP,plasma free MN and NMN levels in study group were higher than those in control group;With the decrease of tumor differentiation in PPGL patients,plasma free MN and NMN levels gradually increased(P＜0.05).Pearson correlation analysis showed that plasma free MN and NMN levels were positively correlated with SBP and DBP in PPGL patients;Spearman correlation analysis showed that plasma free MN and NMN levels were negatively correlated with the degree of tumor differentiation(P＜0.05).ROC curve analysis results showed that the area under the ROC curve(AUC)predicted PPGL by the combined prediction of plasma free MN and NMN levels was larger than the AUC predicted by them alone.Conclusion The detection of plasma free MN and NMN levels can be used as an important indicator for the diagnosis of PPGL,and is closely related to the degree of tumor differentiation.
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