Expression of human endogenous retrovirus-H long terminal repeat associated protein 2,lymphocyte-activation gene 3 and integrin-linked kinase in cancer tissues and their relationship with clinic pathology characteristics in patients with lung adenocarcinom
Expression of human endogenous retrovirus-H long terminal repeat associated protein 2,lymphocyte-activation gene 3 and integrin-linked kinase in cancer tissues and their relationship with clinic pathology characteristics in patients with lung adenocarcinom
Objective To explore the expression of human endogenous retrovirus-H long terminal repeat associated protein 2(HHLA2),lymphocyte-activation gene 3(LAG-3)and integrin-linked kinase(ILK)in cancer tissues and their relationship with clinic pathology characteristics in patients with lung adenocarcinoma(LUAD).Methods The expressions of HHLA2,LAG-3 and ILK in cancer tissues and para-cancerous tissues of 106 LUAD patients were detected.According to the expressions of 3 indexes in cancer tissues,all patients were divided into high-expression HHLA2 group(85 cases)and low-expression HHLA2 group(21 cases),high-expression LAG-3 group(65 cases)and low-expression LAG-3 group(41 cases),high-expression ILK group(78 cases)and low-expression ILK group(28 cases).General data,clinic pathology data and 3-year survival rate were collected and compared between groups.Results The expression levels of HHLA2,LAG-3 and ILK were high in cancer tissues,while which were low in para-cancerous tissues(P＜0.05).The proportions of age≥60 years and lymph node metastasis in HHLA2 high-expression group were higher than those in low-expression HHLA2 group;The proportions of TNM staging at stage Ⅲ and Ⅳ,lymph node metastasis and distant metastasis in high-expression LAG-3 group were higher than those in low-expression LAG-3 group;The proportions of low tissue differentiation,TNM staging at stage Ⅲ and Ⅳ,lymph node metastasis and distant metastasis in high-expression ILK group were higher than those in low-expression ILK group(P＜0.05).3-year survival rates in low-expression HHLA2,LAG-3 and ILK groups were higher than those in corresponding high-expression groups(P＜0.05).Conclusion The expressions of HHLA2,LAG-3 and ILK in cancer tissues are up-regulated in LUAD patients,which have certain relationship with clinic pathology characteristics and prognosis.
关键词
肺腺癌/人内源性逆转录病毒-H长末端重复关联蛋白2/淋巴细胞活化基因3/整合连接激酶/临床病理
Key words
Lung adenocarcinoma/Human endogenous retrovirus-H long terminal repeat associated protein 2/Lymphocyte-activation gene 3/Integrin-linked kinase/Clinic pathology
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