Relationship between brachial-ankle artery pulse wave conduction velocity with plasma renin activity and influencing factors of ambulatory blood pressure control failure in patients with essential hypertension and metabolic syndrome
Relationship between brachial-ankle artery pulse wave conduction velocity with plasma renin activity and influencing factors of ambulatory blood pressure control failure in patients with essential hypertension and metabolic syndrome
Objective To explore the relationship between brachial-ankle artery pulse wave conduction velocity(baPWV)with plasma renin activity(PRA)and influencing factors of ambulatory blood pressure control failure in patients with essential hypertension(EH)and metabolic syndrome(MS).Methods A total of 263 patients with EH were divided into non-MS group(118 cases)and MS group(145 cases)according to whether combined with MS or not.General clinical data,PRA,baPWV and ambulatory blood pressure were compared between two groups.Pearson correlation analysis was used to evaluate correlation between baPWV with PRA and other indexes.Binary logistic regression analysis was used to evaluate influencing factors of ambulatory blood pressure control failure.Results BMI,abdominal circumference,fasting plasma glucose(FPG),2 h plasma glucose post-glycemic load(2h PG),triglyceride,serum uric acid levels and left,right baPWV of patients in MS group were higher than those in non-MS group,high density lipoprotein cholesterol(HDL-C)was lower than that in non-MS group(P＜0.05).Pearson correlation analysis showed that baPWV was positively correlated with FPG and 2h PG(P＜0.001),and negatively correlated with estimated glomerular filtration rate(eGFR)(P＜0.001),while it was not correlated with PRA(P=0.403)in patients with EH;baPWV was negatively correlated with PRA of patients in MS group(P=0.020);while there were no correlation between baPWV with PRA of patients in non-MS group(P=0.632).Binary logistic regression analysis showed that eGFR was an independent protective factor for ambulatory blood pressure control failure of patients in non-MS group(P=0.025),baPWV was an independent risk factor of it(P=0.045),while age was an independent risk factor for ambulatory blood pressure control failure of patients in MS group(P=0.017).Conclusion The lower the PRA,the worse the arterial elasticity in patients with MS and EH.Risk factors for ambulatory blood pressure conduct failure includes eGFR reduction and baPWV increase in EH patients without MS,while age has an independent effect on ambulatory blood pressure conduct failure in EH patients with MS.
维普
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