Objective To analyze systemic immune inflammation index(SII)levels in ulcerative colitis(UC)patients and assess its relationship with disease activity.Methods A total of 161 UC patients(UC group)and 150 patients who had a health checkup during the same period(control group)were included.Disease activity of UC patients was evaluated by modified Mayo score,and they were divided into remission group(26 cases)and active group[135 cases,included mild activity group(30 cases),moderate activity group(67 cases)and severe activity group(38 cases)].General clinical characteristics and laboratory examination indicators of all subjects were collected,and differences in inflammatory indexes of peripheral blood SII,platelets-lymphocytes ratio(PLR),and neutrophils-lymphocytes ratio(NLR)were compared among all groups.Spearmancorrelation analysis was used to assess the correlation between SII and UC activity;receiver operating characteristic(ROC)curve was used to evaluate the predictive value of SII for UC activity severity.Results PLR,PLT count,NLR,neutrophil count(Neu)and SII in patients in UC group were significantly higher than those in control group,while Hb and age were significantly lower than those in control group(P＜0.001).Neu,PLT count,NLR,PLR,SII,C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR)in active group were significantly higher than those in remission group,and LYM was significantly lower than that in remission group(P＜0.05).Neu,PLT count,NLR,PLR,SII,CRP and ESR were all increased successively in mild activity group,moderate activity group and severe activity group,while Hb levels of patients in mild activity group and moderate activity group were higher than those in severe activity group(P＜0.05).Spearman correlation analysis results showed that Neu,PLT count,NLR,PLR,SII,CRP,ESR were positively correlated with UC disease activity and UC activity severity,while Hb was negatively correlated with UC activity severity(P＜0.001).ROC curve analysis results showed that ESR,PLR,PLT,NLR,Neu,CRP and SII had certain predictive value for active UC and severe UC(P＜0.001),among which the AUC of SII was the largest.Conclusion SII may be helpful in assessing UC disease activity and severity of active phase.
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