Predictive efficacy of neutrophil to lymphocyte ratio,D-dimer,interleukin-6 and interferon-γ on risk of in-hospital death in patients with acute Stanford type B aortic dissection
Objective To investigate the predictive efficacy of neutrophil to lymphocyte ratio(NLR),D-dimer(D-D),interleukin(IL)-6 and interferon(IFN)-γ on risk of in-hospital death in patients with acute Stanford type B aortic dissection(AADB).Methods A total of 86 patients with AADB were divided into survival group(71 cases)and death group(15 cases)according to occurrence of end-point events in hospital.NLR,D-D,IL-6 and IFN-γ levels between two groups were compared.Cox regression analysis was used to analyze influencing factors for in-hospital death in patients with AADB.Receiver operating characteristic(ROC)curve was used to analyze predictive efficacy of NLR,D-D,IL-6 and IFN-γon in-hospital death in patients with AADB.Relative risk value was used to analyze effect of positive expressions of NLR,D-D,IL-6 and IFN-γ on risk of in-hospital death in patients with AADB.Results NLR,D-D,IL-6 and IFN-γ levels in patients of death group were higher than those in survival group(P＜0.05).Cox regression analysis result showed that NLR,D-D,IL-6 and IFN-γ were all independent risk factors for in-hospital death in patients with AADB(P＜0.001).The combined efficacy of NLR,D-D,IL-6,and IFN-γ in predicting in-hospital death in patients with AADB was superior to single indicators.In-hospital mortality of patients with AADB with positive expression of NLR,D-D,IL-6 and IFN-γ were all higher than those of patients with negative expression of corresponding index(P＜0.001).Risk value analysis showed that positive expression of NLR,D-D,IL-6 and IFN-γ all significantly increased risk of in-hospital death in patients with AADB(P＜0.001).Conclusion NLR,D-D,IL-6,IFN-γ are independent predictors of in-hospital death in patients with AADB,combination of above 4 index has reliable predictive efficacy.
Acute Stanford type B aortic dissectionNeutrophil to lymphocyte ratioInterleukin-6D-dimerInterferon-γRisk of in-hospital deathPredictive efficacy
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