2型糖尿病患者心外膜脂肪厚度与糖尿病周围神经病变的相关性研究
Correlation study between epicardial fat thickness and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus
杨飞 1谢传庆 1马卫国 1李亚1
作者信息
- 1. 710077 西安,西安医学院第一附属医院内分泌科
- 折叠
摘要
目的 探讨2型糖尿病(T2DM)患者心外膜脂肪厚度(EAT)与糖尿病周围神经病变(DPN)之间的相关性.方法 选择我院收治的T2DM患者293例,根据有无DPN分为DPN组170例和非DPN(NDPN)组123例.收集所有患者的一般临床资料、实验室检查结果及EAT并进行组间比较.采用单因素及多因素logistic回归分析评估T2DM患者DPN发生的影响因素.采用受试者工作特征(ROC)曲线评估相关因素对T2DM患者DPN发生的诊断价值.结果 与NDPN组比较,DPN组患者糖尿病病程、尿微量蛋白/肌酐比值(UACR)、甘油三酯(TG)、EAT及糖尿病性视网膜病变(DR)患者比例均明显升高,尿酸及总胆固醇(TC)水平均明显降低(P＜0.05).多因素logistic回归分析结果显示,糖尿病病程、UACR、EAT均为T2DM患者DPN发生的危险因素(P＜0.05).将EAT以三分位数分为低EAT组、中EAT组及高EAT组,校正相关因素后的多因素logistic回归分析结果显示,中EAT组DPN发生风险是低EAT组的2.37倍,高EAT组DPN发生风险是低EAT组的3.41倍(P＜0.05).ROC曲线分析结果显示,糖尿病病程、UACR及EAT三者联合对DPN的预测价值高于单一指标.结论 EAT升高的T2DM患者更易发生DPN,EAT可能对DPN的发生有一定预测作用.
Abstract
Objective To investigate the correlation between epicardial fat thickness(EAT)and diabetic peripheral neuropathy(DPN)in patients with type 2 diabetes mellitus(T2DM).Methods 293 patients with T2DM admitted to our hospital were selected and divided into DPN group(170 cases)and non-DPN(NDPN)group(123 cases)according to the presence or absence of DPN.General clinical data,laboratory results and EAT of all patients were collected and compared between groups.Univariate and multivariate logistic regression analysis were used to evaluate the influencing factors of DPN in patients with T2DM.Receiver operating characteristic(ROC)curve was used to evaluate the diagnostic value of related factors for DPN in patients with T2DM.Results Compared with NDPN group,duration of diabetes,urinary albumin/creatinine ratio(UACR),triglyceride(TG),EAT and the proportion of diabetic retinopathy(DR)patients in DPN group were significantly increased,and the levels of uric acid and total cholesterol(TC)were significantly decreased(P＜0.05).Multivariate logistic regression analysis showed that diabetes duration,UACR and EAT were risk factors for the development of DPN in patients with T2DM(P＜0.05).EAT was divided into low EAT group,middle EAT group and high EAT group by tertiles,and results of multivariate logistic regression analysis after correcting related factors showed that the risk of DPN occurrence in middle EAT group was 2.37 times higher than that in low EAT group,and the risk of DPN occurrence in high EAT group was 3.41 times higher than that in low EAT group(P＜0.05).Results of the ROC curve analysis showed that diabetes disease duration,UACR and EAT combined had a higher predictive value for DPN than a single indicator.Conclusion T2DM patients with increased EAT are more likely to develop DPN,and EAT may has a certain predictive role in the development of DPN.
关键词
2型糖尿病/糖尿病周围神经病变/心外膜脂肪厚度/相关性研究Key words
Type 2 diabetes/Diabetic peripheral neuropathy/Epicardial adipose thickness/Correlation study引用本文复制引用
基金项目
陕西省重点研发计划(2022SF-162)
出版年
2024
NETL
NSTL
万方数据