十二指肠神经内分泌肿瘤的临床特点及预后分析
Clinicopathological characteristics and prognosis analysis of duodenal neuroendocrine neoplasm
许湘 1马也 1蒋青伟 1徐强 2游燕 3徐天铭1
作者信息
- 1. 100730 北京,中国医学科学院北京协和医学院北京协和医院消化内科
- 2. 100730 北京,中国医学科学院北京协和医学院北京协和医院基本外科
- 3. 100730 北京,中国医学科学院北京协和医学院北京协和医院病理科
- 折叠
摘要
目的 探索十二指肠神经内分泌肿瘤(D-NEN)的临床特点和预后相关因素.方法 回顾性纳入2017年1月～2023年6月于我院住院的D-NEN患者,分析其临床特点、辅助检查结果、病理特征、免疫组化结果、治疗方式及预后情况.采用单因素及多因素cox回归分析评估影响D-NEN不良预后的因素.结果 38例D-NEN患者病理分级均为G1或G2级,临床分期Ⅰ～Ⅳ期分别为13例、9例、9例和7例.中位随访33.0(13.0,55.0)个月,随访期间2例患者死亡,8例出现复发或转移.单因素cox回归分析结果提示肝脏转移和系统免疫炎症指数(SII)≥435.5均与D-NEN患者不良预后相关(P＜0.05),多因素cox回归分析结果提示高SII(≥435.5)是D-NEN患者不良预后的独立预测因素(P＜0.05).结论 D-NEN临床病理特点异质性高,SII可能是其潜在的预后预测指标.
Abstract
Objective To explore the clinicopathological characteristics and prognostic factors of duodenal neuroendocrine neoplasm(D-NEN).Methods A total of 38 D-NEN patients who were hospitalized in our hospital from January 2017 to June 2023 were retrospectively included.The clinical features,auxiliary examination results,pathological features,immunohistochemical results,treatment methods and prognosis were analyzed.Univariate and multivariate cox regression analysis were used to evaluate the factors affecting the adverse prognosis of D-NEN.Results All D-NEN patients'pathologicalgrade were grade G1 or G2.There were 13 patients in clinical stage Ⅰ,9 in stage Ⅱ,9 in stage Ⅲ,and 7 in stage Ⅳ respectively.Within a median follow-up of 33.0(13.0,55.0)months,2 patients died and 8 patients developed recurrence or metastasis during follow-up.Univariate cox regression analysis results indicated that liver metastasis and systemic immunoinflammatory index(SII)≥435.5 were associated with poor prognosis in D-NEN patients(P＜0.05),and multivariate cox regression analysis results indicated that high SII(≥435.5)was an independent predictor of poor prognosis in D-NEN patients(P＜0.05).Conclusion D-NEN shows high clinicopathological heterogeneity,and SII might be a potential predictive factor for its long-term prognosis.
关键词
神经内分泌肿瘤/十二指肠肿瘤/临床病理特点/预后因素Key words
Neuroendocrine neoplasm/Duodenal tumor/Clinicopathological characteristics/Prognosticfactor引用本文复制引用
基金项目
中国医学科学院医学与健康科技创新工程(2021-I2M-1-003)
大学生创新训练项目(2024dcxm055)
出版年
2024
NETL
NSTL
万方数据