Clinical significance of neutrophil to lymphocyte ratio,lymphocyte to monocyte ratio,platelet to lymphocyte ratio and mean platelet volume in myeloproliferative neoplasms
Clinical significance of neutrophil to lymphocyte ratio,lymphocyte to monocyte ratio,platelet to lymphocyte ratio and mean platelet volume in myeloproliferative neoplasms
Objective To investigate the significance of neutrophil to lymphocyte ratio(NLR),lymphocyte to monocyte ratio(LMR),platelet to lymphocyte ratio(PLR)and mean platelet volume(MPV)in myeloproliferative neoplasms(MPN).Methods According to the occurrence of thrombotic events from the diagnosis of MPN to the end of follow-up,225 MPN patients were divided into thrombus group(36 cases)and non-thrombus group(189 cases).Baseline data at first visit were collected and compared between groups.The risk factors of thrombotic events in MPN patients were investigated by univariate and multivariate logistic regression analysis.Receiver operating characteristic(ROC)curve was used to obtain the best cut-off value of relevant indicators for MPN thrombosis and to evaluate the predictive value of relevant factors for MPN thrombosis.Results The age and MPV in thrombus group were higher than those in non-thrombus group(P＜0.05).Multivariate logistic regression analysis showed that LMR＜3.67 and MPV≥9.35 were independent risk factors for thrombotic events in MPN patients(P＜0.05).ROC curve analysis results showed that the area under the curve(AUC)of MPN thrombosis predicted by LMR＜3.67 and MPV ≥9.35 combined was greater than that predicted by them alone(P＜0.05).Conclusion Low LMR and high MPV are associated with MPN thrombosis,and LMR and MPV can be used as predictive tools for thrombotic events in MPN patients.
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