Objective To investigate the expression levels of serum thioredoxin reductase 1(TXNRD1),microRNA-875-5p(miR-875-5p),and their predictive value for maternal and infant outcomes in patients with gestational diabetes mellitus(GDM).Methods A total of 124 cases of GDM patients admitted to our hospital from April 2019 to April 2020 were selected as GDM group,and another 124 cases of healthy pregnant women with normal physical examination in the same period were selected as control group.The patients in GDM group were divided into poor maternal outcome group(46 cases),good maternal outcome group(78 cases)and poor perinatal outcome group(49 cases)and good perinatal outcome group(75 cases)based on maternal outcome and perinatal outcome,respectively.General clinical data,serum TXNRD1,miR-875-5p phase,maternal and perinatal poor outcome were collected and grouped for comparison.Multifactorial logistic regression analysis was used to assess the influencing factors of maternal and infant adverse outcomes in GDM patients;subjects'work characteristics(ROC)curves were used to analyze miR-875-5p and TXNRD1 predictive value for maternal and infant adverse outcomes.Results The rates of preterm labor,cesarean section,postpartum hemorrhage,and total adverse maternal outcomes were significantly higher in GDM group than in control group,and the rates of macrosomia,fetal distress,neonatal asphyxia,neonatal hypoglycemia,hyperbilirubinemia,and total adverse perinatal outcomes were significantly higher in GDM group than in control group(P＜0.05).Multifactorial logistic regression analysis showed that serum miR-875-5p were all protective factors for maternal and perinatal adverse outcomes in GDM patients,and age,pre-pregnancy BMI,poor maternal history,poor glycemic control and serum TXNRD1 were all risk factors(P＜0.05).The ROC curve results showed that the AUC of serum miR-875-5p and TXNRD1 for the combined prediction of maternal and perinatal adverse outcomes was greater than both of them individually predicted.Conclusion Serum miR-875-5p and TXNRD1 were abnormally low and high expressed in GDM patients,respectively,and both had some predictive value for maternal and infant outcomes,and the combined predictive value of the two was higher.
Gestational diabetesThioredoxin reductase 1MicroRNA-875-5pMmaternal and infant outcomes
万方数据
维普
