Correlation analysis of clinical indicators of disease progression in patients with autosomal dominant polycystic kidney disease in southwest Shandong province
Objective The clinical data of patients with autosomal dominant polycystic kidney disease(ADPKD)in southwest Shandong were analyzed,and the clinical indicators related to the progression of ADPKD were analyzed.Methods A total of 200 ADPKD patients were included.By examining each clinical indicator and the estimated glomerular filtration rate(eGFR),the indicators related to the progression of ADPKD were sought.The sample correlation coefficients of eGFR,lg(eGFR)and each index were calculated respectively,and their advantages and disadvantages in linear correlation analysis were compared.Collinear screening was used to further screen indicators,and the mutual influence of relevant indicators was studied through the calculation of sample partial correlation coefficient and complex correlation coefficient.Multiple linear regression analysis model was established to find out the optimal reference index for evaluating the progress of ADPKD.Results In southwest Shandong Province,ADPKD patients with obese and overweight BMI were on average 3.3 to 5.2 years younger than patients with normal and thin BMI.Through the x2 test of each clinical index and eGFR,16 clinical indicators related to the progression of ADPKD were obtained.It was found that lg(eGFR)was more suitable for linear correlation analysis than eGFR.Cystatin C(CysC),β2-microglobulin(β2-MG),blood urea nitrogen(BUN),blood phosphorus(P)and blood uric acid(SUA)were negatively correlated with the progression of ADPKD,whileHb,RBC count,hematocrit value(HCT),bicarbonate(Bicarb),indirect bilirubin(IBiL),lymphocyte count(LYMC),urinary specific gravity(USG),total bilirubin(TBiL),PLT volume(PCT),PLT count and WBC count were positively correlated with the progression of ADPKD(P＜0.05).The relationship between ADPKD progress and related indicators was comprehensive,and the linear regression model of lg(eGFR)constructed with CysC,BUN and Hb was meaningful.Conclusion In southwestern Shandong Province,the overweight and obese patients with ADPKD are generally younger,and the obesity problem of patients deserves attention.There are many indicators related to the progression of ADPKD and they affect each other.CysC,BUN and Hb are better reference indicators.
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