Efficacy of combined induction chemotherapy and concurrent chemoradiotherapy in treating locally advanced non-squamous cell lung cancer and its influence on serum vascular endothelial growth factor,immune function and quality of life
Objective To investigate the efficacy of combining induction chemotherapy with concurrent chemoradiotherapy in the treatment of patients diagnosed with locally advanced non-squamous cell lung cancer(NSCLC),and evaluating its possible impacts on serum vascular endothelial growth factor,immune function and quality of life.Methods 80 patients with locally advanced NSCLC were divided into control group and observation group through random assignment,40 cases in each group.Control group underwent concurrent chemoradiotherapy,and observation group underwent with induction chemotherapy based on the treatment regimen of the control group.The therapeutic effect,vascular endothelial growth factor[factor for vascular endothelial growth(VEGF),growth gactor derived from platelets(PDGF),growth factor for fibroblasts(FGF)],immune function(IgG,IgM,IgA)and quality of life[European Cancer Research Group lung cancer specific quality of life questionnaire(QLQ-LC13)score]were compared among the two groups,and the progression-free survival and overall survival in the two groups were analyzed by Kaplan-Meier curve.Results After treatment,the total remission rate in the observation group was significantly higher than that in control group(P＜0.05).Compared with those before treatment in the same group,the levels of VEGF,PDGF,FGF,IgG,IgM,IgA and the scores of QLQ-LC13 questionnaire in both the observation group and the control group decreased(P＜0.05).Compared with control group in the same period,the above indicators in observation group were significantly lower than those in control group(P＜0.05).The progression-free survival time and overall survival time in observation group were significantly longer than those in control group.Conclusion Combined concurrent chemoradiotherapy induction chemotherapy can achieve significant efficacy for patients diagnosed with locally advanced non-squamous cell lung cancer,and it can help to stop the spread of tumor,regulate the immune function and enhance the quality of life of patients,and it has positive significance on prolonging the survival time.
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