Objective To explore the diagnostic and prognostic assessment values of nerve con-duction block(CB)and ganglioside antibody in patients with Guillain-Barré syndrome(GBS).Methods Retrospective analysis was run on clinical and neurophysiological characteristics of 34 patients diag-nosed with acute motor axonal neuropathy(AMAN)or acute inflammatory demyelinating polyneurop-athy(AIDP)admitted to Zhengzhou Central Hospital from January 2018 to August 2022.The differ-ences in the highest Hughes score and the decrease in Hughes score after 4 weeks were compared be-tween two groups of patients with positive and negative serum anti-ganglioside antibody,and between two groups of patients with nerve CB.Results Among the 34 patients in this study,there were 20 patients with AMAN(AMAN group)and 14 patients with AIDP(AIDP group).Six patients in the AMAN group experienced reversible nerve CB.There were significant differences in the decrease in Hughes scores between the patients with CB and the patients without CB in AMAN group,and be-tween the patients with CB in AMAN group and the patients with CB in AIDP group(P＜0.05).A-mong 34 patients,13 patients were positive for serum ganglioside antibody,including 8 patients in AMAN group and 5 patients in AIDP group.There is no statistically significant difference in the de-crease in H ughes scores between patients with positive and negative ganglioside antibody(P＞0.05).Conclusion AMAN patients with reversible nerve CB might have fast clinical recovery,better than AMAN patients without nerve CB and AIDP patients with nerve CB.Ganglioside antibody might not be associated with the short-term prognosis of GBS.
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