Objective To explore the risk factors of post-traumatic epilepsy(PTE)in children with mild and medium traumatic brain injury(TBI),and to provide reference for clinical prevention and treatment of PTE.Methods The clinical data of 259 children with mild and medium craniocerebral injuries who were admitted to the Department of Neurosurgery,416 Hospital,the Second Affiliated Hospital of Chengdu Medical College,from January 1,2015 to January 1,2023 were analyzed retrospectively.259 children were classified into PTE group(52)and non-PTE group(207)based on hospitalization and diagnosis of epilepsy within 6 months of discharge.Univariate analysis and multivariate logistic regression were used to analyze the risk factors of PTE after mild and medium TBI in children.Results The results of univariate analysis showed that there were statistically significant differences between PTE and non-PTE groups in the categories of brain injury indicated by magnetic resonance imaging(MRI)showed hemosiderin deposition,emergency computer tomography(CT),abnormal categories of electroencephalogram(EEG),interleukin(IL)-1,IL-6,IL-8 and fibrinogen elevated levels(P＜0.05).Multivariate logistic regression analysis showed that emergency CT showed traumatic subarachnoid hemorrhage,MRI showed hemositin deposition,EEG showed decreased or disappeared sleep spindles,and elevated IL-8 were independent risk factors for PTE in children with mild and moderate head injury(P＜0.05).Conclusions Emergency CT shows traumatic subarachnoid hemorrhage.MRI shows hemosiderin deposition.EEG shows decreased or disappeared sleep spindles,and elevates IL-8 are independent risk factors for PTE after mild and moderate TBI in children.The incidence of PTE can be reduced by taking relevant prevention and treatment measures for mild and medium TBI children with the above risk factors.
维普
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