Objective To explore the etiology,clinical manifestation,imaging characteristics and treatment of intracranial hemorrhage in patients combined with low intracranial pressure syndrome.Methods The clinical data of 14 patients with low intracranial pressure syndrome and intracranial hemorrhage who were admitted to Department of Neurosurgery,Zhangjiagang Hospital Affiliated to Suzhou University from January 2015 to December 2022 were analyzed retrospectively.Regular follow-up was conducted to understand the prognosis and outcome.Results Among 14 patients with low intracranial pressure syndrome,13 patients had orthostatic headache.4 patients with spontaneous intracranial hypotension syndrome combined with bilateral chronic subdural hematoma underwent enhanced cranial magnetic resonance imaging(MRI)to demonstrate imaging features such as subdural fluid collection,enhancement of pachymeninges,engorgement of venous structures,pituitary enlargement and sagging of the brain.Treatment methods included surgical operation(3 cases)and conservative treatment(1 case).10 cases of traumatic intracranial hypotension syndrome with intracranial hemorrhage were treated conservatively in 7 cases,craniotomy and drainage surgery in 2,and craniotomy and hematoma removal surgery in 1.After treatment,the relevant symptoms of all patients were significantly improved or disappeared.Conclusions For patients with low intracranial pressure syndrome and intracranial hemorrhage,conservative treatment or surgical treatment should be selected according to the individual situation of the patient.Early identification of the etiology contributes to the optimization of clinical treatment options,improving patients'neurological function and prognosis.