Reactive oxygen species(ROS)plays an important role in regulating the physiological function of organisms.However,excessive ROS content may cause oxidative stress and biomolecule destruction,resulting in inflammation,tumors,neurodegenerative diseases and other diseases.Nanozymes with the activities of antioxidant enzymes such as superoxide dismutase or catalase can reduce the content of ROS in tissue,regulate the dynamic balance of redox and reduce the damage of ROS to tissue,and the nanozymes has the advantages of strong stability,adjustable activity and simple synthesis conditions.In this paper,the latest research on nanozymes in the treatment of ROS-related brain diseases are reviewed.