Glioblastoma(GBM)is a high-grade malignant tumor originating from intracranial glia,with a high recurrence rate and poor prognosis.The standard treatment mode is surgical resection of tumor combined with radiotherapy and chemotherapy,but the effect is greatly reduced due to the limitation of Blood-brain barrier and the mechanism of drug resistance to chemotherapy drugs.In recent years,according to the continuous research on the effect and drug resistance mechanism of the existing Temozolomide,Nitroso,Bevacizumab and other commonly used anti GBM drugs,a variety of effective combination therapies have been found.In addition,exploring new methods in the field of nanotechnology has had a significant impact on the process of GBM.This article reviews the latest research progress on the resistance mechanisms,effective combination therapy,and other strategies to improve efficacy of commonly used anti GBM chemotherapy drugs.
国家科技期刊平台
NSTL
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