Glioma are the most common primary malignant tumors of the central nervous system,with high invasiveness and relatively poor prognosis.In the comprehensive treatment of glioma,radiotherapy is one of the most commonly used and effective methods.However,the resistance of glioma to radiotherapy and the side effects caused by radiotherapy are still inevitable issues.In recent years,with the rapid development of nanotechnology in the medical field,nano radiotherapy sensitizers have received widespread attention in the treatment of gliomas due to their unique physicochemical properties,providing new opportunities for enhancing radiotherapy efficacy.This article elaborates on the application of nanoradiotherapy sensitizers in gliomas,summarizes and prospects the challenges and development prospects faced by nanoradiotherapy sensitizers in their application.