首页|姜黄素衍生物及其生物学功能研究进展

姜黄素衍生物及其生物学功能研究进展

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姜黄素是从姜黄等植物根茎中提取的一种天然β-二酮类多酚化合物.姜黄素具有水溶性低、化学性质不稳定以及生物利用率低等缺点,因而围绕改善姜黄素生化结构缺陷的研究衍生出多种的姜黄素衍生物.姜黄素及其衍生物具有抗病毒、抗肿瘤、抗抑郁以及保护神经等多种生理功能,因而成为目前研究比较热门并且具有发展前景的药物.总结现有部分姜黄素衍生物结构特点及其分类,同时阐明姜黄素抗氧化、抗肿瘤等作用的分子机理,为姜黄素衍生物的结构探究及其生理功能的进一步研究提供一定的视角.
Research Progresses on Curcumin Derivatives and Their Biological Functions
Curcumin is a natural β-diketone polyphenolic compound extracted from the rhizome of Curcuma longa and other plants.Due to the disadvantages of poor solubility in water,unstable chemical properties and low bioavailability,therefore,a variety of curcumin derivatives or analogues have been designed or synthesized to optimize the beneficial properties of curcumin.Extensive experimental and clinical research have proven that curcumin and its derivatives present many biochemical characteristics,such as anti-virus,anti-tumor,anti-depression,nerve protection and so on,so they have been considered one of the promising drugs.In this review,we have summarized the structural features of some available curcumin derivatives and their classification,and subsequently elucidated the molecular mechanisms of curcumin in antioxida-tion and anti-tumor.It aims to provides a certain perspective for further research on the structure and bio-chemical functions of curcumin derivatives.

CurcuminCurcumin derivativesbiological functionanti-oxidationanti-tumor

王扬晗、朱鲁杰、王飞、王琪琳

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聊城大学农业与生物学院,山东聊城 252059

聊城大学药学与食品工程学院,山东聊城 252059

姜黄素 姜黄素衍生物 生物学作用 抗氧化 抗肿瘤

2025

聊城大学学报(自然科学版)
聊城大学

聊城大学学报(自然科学版)

影响因子:0.343
ISSN:1672-6634
年,卷(期):2025.38(1)