泛素特异性蛋白酶7功能和在结直肠癌中的研究进展
Function and research progress of ubiquitin-specific protease 7 in colorectal cancer
付锦程 1付涛2
作者信息
- 1. 430060 武汉大学人民医院胃肠外Ⅱ科
- 2. 430060 武汉大学人民医院胃肠外Ⅱ科;青岛市市立医院(集团)普外中心
- 折叠
摘要
泛素特异性蛋白酶7(ubiquitin-specific protease 7.USP7)是一种广泛参与各种细胞过程的去泛素化酶.USP7在调控细胞增殖与凋亡,细胞分裂、分化,DNA损伤修复,表观遗传学调控等生物学过程中有关键作用.本文对USP7的结构及其广泛的生物学功能进行综述.
Abstract
Ubiquitin-specific protease 7(USP7)is a deubiquitinating enzyme involved in a wide range of cellular processes,playing a key role in the regulation of cell proliferation and apoptosis,cell division,differentiation,DNA damage repair,epigenetic regulation and other biological processes.This article briefly summarizes the structure and extensive biological functions of USP7,and also describes the research progress of USP7 in colorectal cancer in recent years and potential directions for future research.
关键词
泛素特异蛋白酶7/去泛素化/结直肠癌Key words
ubiquitin-specific protease 7/deubiquitination/colorectal cancer引用本文复制引用
基金项目
青岛市市立医院人才引进基金(8-013-12)
出版年
2024
NETL
NSTL
万方数据